With the Missing Poster, a run may be taken to the end with an easier character and finished as The Lost by dying on purpose, granting the unlock for The Lost without doing a full run.This makes pills more useful since the pill pool is more likely to have positive effects. The Lost does not receive Bad Trip or Health Down pills.It is recommended to use Slot Machines as much as possible to obtain Pretty Flies.

Three orbitals of any kind absorb nearly all projectiles.If an option to reroll items is found, they can be changed if not yet picked up. The same applies to useless items (except while holding the D4, that can reroll the passive items).It is recommended to avoid picking them up in case the D20, a Dice Room (with 3 pips, 2 if the hearts spawn in the Dice Room), or a Dice Shard is found later on. The Lost will absorb Soul Hearts, Black Hearts, and Eternal Hearts by picking them up, but will not gain any health from them.Bombs can be used to escape rooms you think you cannot handle.If the player manages to get good item combinations, the difficulty will not matter much. Always play on hard mode, as hard mode is required to unlock Godhead.The Lost's ability to fly can be used to hide safely above obstacles and pits, avoiding enemies and projectile contact.It is recommended to have advanced knowledge of all types of rooms, champions, and enemies.

This can be done by donating 879 coins to the Greed Donation Machine.

It is absolutely suggested to unlock The Lost's intrinsic Holy Mantle greatly lowering the difficulty of his usage.

Before attempting runs with The Lost, unlock any items that may be helpful for The Lost.

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